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Elevated mortality following diagnosis with a treatable disease: tuberculosis
K Tocque1, R P Convrey, M A Bellis
1Centre for Public Health, John Moores University, Liverpool, Merseyside, United Kingdom. k.tocque@livjm.ac.uk
Previous tuberculosis (TB) diagnosis significantly increases mortality risk compared to the general population. This elevated risk is particularly pronounced for lung cancer in younger patients, highlighting the long-term health consequences of TB.
Area of Science:
- Public Health
- Epidemiology
- Respiratory Medicine
Background:
- Tuberculosis (TB) is a significant global health concern.
- Understanding the long-term mortality risks associated with a prior TB diagnosis is crucial for public health strategies.
Purpose of the Study:
- To investigate the association between a previous diagnosis of tuberculosis (TB) and subsequent mortality risk.
- To compare mortality rates in TB patients with the general population.
Main Methods:
- A retrospective survey was conducted on 439 TB patients in Liverpool over an 8-year period.
- Mortality data was compared with the general population, and causes of death were identified from death certificates.
Main Results:
- Of 439 TB patients, 104 (23.7%) died during the follow-up period.
- The standardized mortality ratio (SMR) for 45-54 year olds was 1101 (11-fold higher than expected).
- Lung cancer mortality was 30-fold higher in TB patients under 75 compared to the general population.
Conclusions:
- Tuberculosis diagnosis is associated with increased overall mortality.
- TB patients under 75 exhibit a significantly higher risk of lung cancer mortality.
- Mortality in older TB patients is often due to TB itself or other chest diseases, suggesting shared risk factors.
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