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Related Experiment Videos

Bivalirudin: a review.

Theodore E Warkentin1, Andreas Koster

  • 1Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. twarken@mcmaster.ca

Expert Opinion on Pharmacotherapy
|July 15, 2005
PubMed
Summary
This summary is machine-generated.

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Bivalirudin is a direct thrombin inhibitor drug designed as a hirudin analogue. It offers advantages over hirudin and is approved for angioplasty, with ongoing research for cardiac surgery and heparin-induced thrombocytopenia.

Area of Science:

  • Pharmacology
  • Biochemistry

Background:

  • Bivalirudin is a 20-amino acid oligopeptide designed as a hirudin analogue.
  • It functions as a bivalent thrombin inhibitor, targeting both the fibrinogen-binding site and the active site of thrombin.

Purpose of the Study:

  • To describe the pharmacological properties and clinical applications of bivalirudin.
  • To highlight its advantages over traditional anticoagulants like hirudin.

Main Methods:

  • Rational drug design was employed to create bivalirudin.
  • Pharmacological advantages were assessed through comparative analysis with hirudin.

Main Results:

  • Bivalirudin exhibits enzymic metabolism, reducing renal clearance dependence.
  • It demonstrates low immunogenicity, minimizing anaphylaxis risk.

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  • Approved for percutaneous transluminal coronary angioplasty (PTCA).

    • Conclusions:

    • Bivalirudin presents a favorable pharmacological profile compared to hirudin.
    • Its efficacy is established in PTCA and under investigation for cardiac surgery and heparin-induced thrombocytopenia.