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Published on: March 28, 2017
The pharmacogenetics of coumarin therapy
Deepak Voora1, Howard L McLeod, Charles Eby
1Washington University School of Medicine, Departments of Medicine and of Pathology, St. Louis, MO 63110, USA.
Abstract:
Vitamin K antagonists (coumarins) are widely-used oral anticoagulants for the prevention of venous thromboembolism and strokes. Wide inter-individual variation in dose response and frequent bleeds characterize the initiation of coumarin therapy. Over the past 10 years both genetic and nongenetic determinants of coumarin dose response have been identified. A comprehensive pharmacogenetics approach to warfarin therapy has the potential to improve the safety and efficiency of warfarin initiation.
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