Related Experiment Videos
Trisomy 8p: unusual origin detected by fluorescence in situ hybridization
C M Moore1, K Barnum, C I Kaye
1Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.
Human Genetics
|May 1, 1992
Abstract:
Chromosomal analysis of a neonate with brain and heart abnormalities revealed trisomy for 8p. The mother's karyotype showed 47 chromosomes with one chromosome 8 being represented as two separate chromosomes, an acrocentric 8p and a telocentric 8q. G-banding and silver staining revealed a satellite and nucleolus organizing region (NOR) on the 8p. Centromeric-specific probes to the centromeres of chromosomes 8, 15, 13/21, 22 and the acrocentric chromosomes revealed that only the 8q centromere was of chromosome-8 origin, while the 8p centromere was of chromosome-14 origin.