Reduced prevalence of Epstein-Barr virus-related lymphocryptovirus infection in sera from a new world primate
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Updated: Aug 17, 2026
Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Mark H Fogg1, Angela Carville, Jennifer Cameron
1Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. fwang@rics.bwh.harvard.edu
Abstract:
The recent discovery of an Epstein-Barr virus (EBV)-related lymphocryptovirus (LCV) naturally infecting common marmosets demonstrated that gamma-1 herpesviruses are not limited to human and Old World nonhuman primate hosts. We developed serologic assays to detect serum antibodies against lytic- and latent-infection marmoset LCV antigens in order to perform the first seroepidemiologic study of LCV infection in New World primates. In three different domestic colonies and in animals recently captured from the wild, we found that the seroprevalence of marmoset LCV infection was not as ubiquitous as with EBV or Old World LCV. These biologic differences in LCV infection of New World versus human and Old World primate hosts correlate with the evolution of the LCV viral gene repertoire.
