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Related Experiment Video

Updated: May 27, 2026

Isolation of Stem Cells from Human Pancreatic Cancer Xenografts

Isolation of Stem Cells from Human Pancreatic Cancer Xenografts

Published on: September 26, 2010

Gastrointestinal stem cells. I. Pancreatic stem cells.

Bernat Soria¹, Francisco J Bedoya, Franz Martin

¹Institute of Bioengineering, Ctra. Alicante-Valencia N332, s/n, Campus de San Juan, University Miguel Hernandez, E-03550 San Juan de Alicante, Spain. bernat.soria@umh.es

American Journal of Physiology. Gastrointestinal and Liver Physiology

|July 15, 2005

Summary

Stem cell therapy offers a promising avenue for diabetes treatment by generating insulin-producing beta-cells. Research shows these cells can normalize blood glucose in diabetic models, warranting further investigation for a potential cure.

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Published on: March 27, 2019

Area of Science:

Regenerative Medicine
Endocrinology
Cell Therapy

Background:

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia.
Pancreatic islet transplantation is an established cell therapy for type 1 diabetes.
Limitations of donor-derived islets necessitate alternative cell sources.

Purpose of the Study:

To explore the potential of stem cells for generating functional beta-cells.
To evaluate the efficacy of stem cell-derived beta-cells in preclinical diabetes models.
To assess the viability of stem cell-based therapies for curing diabetes.

Main Methods:

Utilizing embryonic and adult stem cells for differentiation into insulin-secreting cells.
Transplantation of generated beta-cells into diabetic animal models.
Monitoring of blood glucose normalization and glycemic control post-transplantation.

Main Results:

Successful generation of insulin-secreting cells from various stem cell sources.
Demonstrated normalization of blood glucose levels in transplanted diabetic animal models.
Evidence of functional beta-cell engraftment and insulin production.

Conclusions:

Stem cells hold significant potential for generating functional beta-cells for diabetes therapy.
Transplantation of stem cell-derived beta-cells shows promise in restoring glycemic control.
Continued stem cell research is crucial for developing a definitive cure for diabetes.