Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amniotic membrane transplantation for ocular surface reconstruction.

Merle Fernandes1, Mittanamalli S Sridhar, Virender S Sangwan

  • 1Cornea and Anterior Segment Service, LV Prasad Eye Institute, LV Prasad Marg, Hyderabad, India. fernandes@lvpei.org

Cornea
|July 15, 2005
PubMed
Summary

Amniotic membrane transplantation aids healing in various eye conditions by reducing inflammation and promoting tissue repair. Further research is needed to fully understand its benefits beyond acting as a biologic contact lens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline Demographics and Topographic Features in Keratoconic Eyes With Hydrops After Ipsilateral Prior Corneal Cross-linking.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2026
Same author

Eye research in India - evolution, current status, and future.

Indian journal of ophthalmology·2026
Same author

Regulation of immunological equilibrium by IL-6/STAT3 in glaucomatous irises and its effect on filtering bleb success.

Indian journal of ophthalmology·2026
Same author

Efficacy of natamycin monotherapy versus combination therapy with voriconazole for fungal keratitis: a randomised clinical trial.

The British journal of ophthalmology·2025
Same author

Atypical progression of microsporidial keratoconjunctivitis to immune ring keratitis: a case report.

International journal of ophthalmology·2025
Same author

Sustainable ophthalmology: an overview of concepts and practices.

Eye (London, England)·2025

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Amniotic membrane, a multi-layered biologic tissue, has a long history of use in wound healing, initially for skin burns in 1910 and later for ocular surface defects starting in 1940.
  • Its use in ophthalmology was revitalized in the 1990s due to its demonstrated ability to mitigate ocular inflammation and scarring.
  • Key properties contributing to its efficacy include promoting rapid epithelialization via growth factors and possessing inherent antimicrobial characteristics.

Purpose of the Study:

  • To review the current applications and benefits of amniotic membrane transplantation in ophthalmology.
  • To explore the potential of amniotic membrane in treating various ocular disorders.
  • To discuss the future prospects of amniotic membrane transplantation, particularly in limbal stem cell research.

Related Experiment Videos

Main Methods:

  • Literature review of studies on amniotic membrane transplantation in ophthalmology.
  • Analysis of the mechanisms underlying amniotic membrane's therapeutic effects.
  • Evaluation of its role in managing ocular surface diseases and promoting healing.

Main Results:

  • Amniotic membrane transplantation has proven beneficial in specific ocular pathologies, though not universally.
  • Its regenerative properties are attributed to growth factors that accelerate epithelialization.
  • Antimicrobial properties further contribute to its therapeutic value in ocular surface management.

Conclusions:

  • Amniotic membrane transplantation is a valuable therapeutic option for select ocular conditions, offering anti-inflammatory and regenerative benefits.
  • While effective, its precise mechanism of action, particularly whether it acts solely as a biologic contact lens or offers additional benefits, requires further investigation.
  • The future of amniotic membrane transplantation holds significant promise, especially concerning its integration with limbal stem cell research for treating severe ocular surface diseases.