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Central corneal mechanical sensitivity in pseudoexfoliation syndrome
Efstathios T Detorakis1, Stavrenia Koukoula, Fotios Chrisohoou
1Department of Ophthalmology, Democritus University of Thrace, Thrace, Greece. detorakis@hotmail.com
Cornea
|July 15, 2005
Summary
Pseudoexfoliation syndrome (PEX) is associated with reduced corneal sensitivity and tear film deficiencies. This study found significantly lower central corneal mechanical sensitivity (CCMS) in PEX patients compared to controls.
Area of Science:
- Ophthalmology
- Corneal Science
- Ocular Surface Disease
Background:
- Pseudoexfoliation syndrome (PEX) is linked to ocular surface issues, including tear film disturbances.
- Tear film deficiencies in PEX are known to correlate with altered corneal sensitivity.
Purpose of the Study:
- To evaluate central corneal mechanical sensitivity (CCMS) in patients diagnosed with pseudoexfoliation syndrome (PEX).
Main Methods:
- A study group (SG) of 40 PEX patients and a control group (CG) of 38 age- and gender-matched individuals were recruited.
- Central corneal mechanical sensitivity (CCMS) was measured using a Cochet-Bonnet esthesiometer.
- Schirmer test (ST) and tear break-up time (BUT) were performed to assess tear film status.
Main Results:
- PEX patients exhibited significantly lower Schirmer (ST) scores and tear break-up time (BUT) compared to controls.
- Central corneal mechanical sensitivity (CCMS) was significantly reduced in the PEX group (P=0.02).
- No significant difference in central corneal thickness (CCT) was observed between the PEX and control groups.
Conclusions:
- Reduced CCMS in PEX may be linked to diminished ST and BUT scores.
- Direct involvement of sensory nerves in PEX could contribute to decreased corneal sensitivity.
- The reduction in CCMS has potential implications for managing PEX patients.