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Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population
P Pearson1, J Britton, T McKeever
1Division of Respiratory Medicine, University of Nottingham, Nottingham City Hospital, Nottingham, UK.
Background:
Increased dietary intake of antioxidants has been associated with higher lung function, but few studies have used biological markers of antioxidant intake.
Objective:
This study aimed to determine if antioxidant status, as measured by blood levels, influences lung function.
Design:
Using a random subsample of 479 participants, aged 18-65 y old, from a larger cross-sectional observational study, the association of forced expiratory volume in 1 s (FEV1) with plasma copper, vitamin C, vitamin E and serum selenium was assessed.
Results:
An s.d. increase in blood copper level was associated with a difference in FEV1 of -48 ml (95% confidence intervals: -95, -2 ml, P = 0.04), vitamin C +49 ml (+4, +94, P = 0.03), vitamin E -15 ml (-62, +32, P = 0.53) and selenium +52 ml (+7, +96, P = 0.02). The sizes of association were not appreciably altered in a mutually adjusted model.
Conclusions:
Higher levels of serum vitamin C and selenium appear to be associated with higher FEV1. The association between higher serum copper and lower FEV1 requires further study in view of the ubiquitous exposure to this mineral.
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