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Related Experiment Videos

Receptors that mediate cellular dependence.

D E Bredesen1, P Mehlen, S Rabizadeh

  • 1The Buck Institute for Age Research, Novato, CA 94945, USA. dbredesen@buckinstitute.org

Cell Death and Differentiation
|July 15, 2005
PubMed
Summary
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Cells require survival signals, and their withdrawal triggers apoptosis via dependence receptors. These receptors activate cell death pathways, impacting development, cancer, and neurodegeneration.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Apoptosis Signaling

Background:

  • Cellular survival is contingent upon trophic factors and prosurvival signals.
  • Withdrawal of these signals initiates apoptosis through loss of antiapoptotic signaling and activation of proapoptotic pathways.
  • Specific receptors, termed dependence receptors, mediate apoptosis upon signal withdrawal.

Purpose of the Study:

  • To elucidate the role and mechanism of dependence receptors in cellular survival and apoptosis.
  • To explore the involvement of dependence receptors in physiological and pathological processes.
  • To understand how dependence receptors integrate survival and death signals.

Main Methods:

  • Mechanistic studies involving dependence receptors and caspases.

Related Experiment Videos

  • Analysis of ligand-dependent complex formation.
  • Investigation of caspase activation pathways upon ligand withdrawal.
  • Examination of receptor cleavage and release of proapoptotic peptides.

    • Main Results:

    • Dependence receptors activate apoptotic pathways upon withdrawal of trophic factors or other supportive stimuli.
    • These receptors form ligand-dependent complexes with specific caspases.
    • Absence of ligand leads to caspase activation, often involving receptor cleavage and release of proapoptotic peptides.
    • Dependence receptors are implicated in developmental cell death, carcinogenesis, metastasis, and neurodegeneration.

    Conclusions:

    • Dependence receptors are critical regulators of apoptosis, linking survival signal status to cell fate.
    • Their aberrant function may contribute to diseases like cancer and neurodegenerative disorders.
    • Dependence receptors function as a molecular integration system for cellular signals, analogous to neuronal integration.