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Factor V Leiden mutation in cerebrovascular disease
Nur Buyru1, Julide Altinisik, Goksel Somay
1Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul University, Istanbul, Turkey. nbuyru@yahoo.com
Summary
Factor V Leiden mutation, a common cause of venous thrombosis, was investigated for its link to cerebrovascular disease. This study found no association between the Factor V Leiden mutation and ischemic stroke or intracerebral hemorrhage in adults.
Area of Science:
- Hematology
- Neurology
- Genetics
Background:
- Factor V Leiden mutation is a frequent cause of venous thrombosis.
- Its association with cerebrovascular disease in adults remains unclear.
- Venous thrombosis and cerebrovascular events share some risk factors.
Purpose of the Study:
- To investigate the potential association between the Factor V Leiden mutation and cerebrovascular disease in adult patients.
- To determine if the mutation is a risk factor for ischemic stroke or intracerebral hemorrhage.
Main Methods:
- Genotyping for the Factor V Leiden mutation using polymerase chain reaction and restriction enzyme digestion.
- Study included 29 ischemic stroke patients, 20 intracerebral hemorrhage patients, and 20 control subjects.
- Subgroup analyses were performed based on age, smoking status, and comorbidities.
Main Results:
- No statistically significant association was found between the Factor V Leiden mutation and ischemic stroke.
- No statistically significant association was found between the Factor V Leiden mutation and intracerebral hemorrhage.
- Subgroup analyses did not reveal any association in specific patient demographics or clinical conditions.
Conclusions:
- The Factor V Leiden mutation does not appear to be a risk factor for cerebrovascular disease in the adult population studied.
- Further research may be warranted to explore other genetic or environmental factors contributing to cerebrovascular events.