Related Experiment Video
Updated: Aug 17, 2026

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
An overview of Eastern Cooperative Oncology Group stage III non-small cell lung cancer studies
1Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1650 Orleans Street, Baltimore, MD 21231-1000, USA. ettinda@jhmi.edu
Abstract:
The Eastern Cooperative Oncology Group conducts phase II and III trials for the treatment of resectable and unresectable stage III non-small cell lung cancer, and also participates in a number of Intergroup studies. For resectable disease, the Eastern Cooperative Oncology Group is participating in a phase III prospective randomized, double-blind, placebo-controlled trial of the epidermal growth factor receptor antagonist gefitinib (ZD1839), a phase II trial for superior sulcus tumors of induction chemoradiotherapy with cisplatin/etoposide followed by surgical resection, followed by docetaxel. For unresectable disease, a phase III trial of carboplatin, paclitaxel, and thoracic radiation therapy with or without thalidomide is underway. Proposed studies include a feasibility phase II study of chemotherapy/hyperfractionated accelerated radiation therapy (HART) + cetuximab (an antibody specific for epidermal growth factor receptor) and a phase II trial of pharmcogenomics-directed adjuvant chemotherapy for completely resected non-small cell lung cancer.
Related Concept Videos
Treatment Resistent Cancers
Treatment Resistant Cancers
Clinical Trials: Overview
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...