Related Experiment Videos
Lack of interaction between cefpirome and alcohol
H B Lassman1, J W Hubbard, B L Chen
1Clinical Pharmacology Section, Hoechst-Roussel Pharmaceuticals Inc., Somerville, New Jersey 08876-1258.
The Journal of Antimicrobial Chemotherapy
|April 1, 1992
Summary
This study found that cefpirome, an antibiotic, does not interfere with alcohol metabolism in healthy males. Cefpirome administration did not cause adverse effects or disulfiram-like reactions when alcohol was consumed.
Area of Science:
- Pharmacology
- Clinical Pharmacology
- Drug Interactions
Background:
- Cefpirome is a cephalosporin antibiotic.
- The potential for drug interactions, particularly with alcohol, is a critical consideration for antibiotic safety.
- Disulfiram-like reactions are a concern with certain antimicrobial agents.
Purpose of the Study:
- To evaluate the safety and tolerability of cefpirome in healthy males.
- To investigate the effect of cefpirome on alcohol pharmacokinetics.
- To determine if cefpirome causes disulfiram-like reactions with alcohol consumption.
Main Methods:
- An observer-blind, randomized, placebo-controlled, crossover study.
- 22 healthy male subjects received intravenous cefpirome (2 g) or placebo.
- Subjects consumed alcohol (0.5 g/kg) one hour post-administration, with a seven-day washout period.
Main Results:
- No statistically significant differences in alcohol pharmacokinetic parameters between cefpirome and placebo groups.
- No adverse events or disulfiram-like reactions were reported.
- Cefpirome was well-tolerated at a 2 g intravenous dose.
Conclusions:
- Pre-treatment with cefpirome does not adversely affect alcohol metabolism in healthy males.
- Cefpirome is safe and well-tolerated in this population.
- Cefpirome does not appear to pose a risk for disulfiram-like reactions with alcohol.