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Vagal function impairment after exercise training.

C E Negrao1, E D Moreira, M C Santos

  • 1Heart Institute, University Hospital, Faculty of Medicine, Sao Paulo, Brazil.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 1, 1992
PubMed
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Exercise training in rats significantly lowers resting heart rate and impairs vagal function. This suggests that adaptations in pacemaker cells, not just autonomic tone, contribute to exercise-induced bradycardia.

Area of Science:

  • Cardiovascular Physiology
  • Exercise Physiology
  • Autonomic Nervous System Function

Background:

  • Regular exercise training is known to induce cardiovascular adaptations.
  • Vagal tone plays a crucial role in regulating heart rate and overall cardiovascular function.
  • Understanding the impact of training on autonomic control is essential for optimizing exercise protocols.

Purpose of the Study:

  • To investigate the effects of a 13-week exercise training program on vagal function in rats.
  • To compare the autonomic nervous system responses between trained and sedentary rats.
  • To elucidate the mechanisms underlying exercise-induced bradycardia.

Main Methods:

  • Treadmill exercise training for 13 weeks (1 h/day, 5 days/week).
  • Assessment of resting heart rate (HR) in trained (T) and sedentary (S) rats.

Related Experiment Videos

  • Pharmacological blockade (methylatropine and propranolol) to determine intrinsic HR.
  • Evaluation of baroreflex sensitivity and vagal nerve stimulation responses.

    • Main Results:

    • Trained rats exhibited a significantly lower resting HR compared to sedentary rats.
    • Intrinsic HR was markedly reduced in trained rats after autonomic blockade.
    • Depressed vagal and sympathetic tonus, reduced baroreflex bradycardia, and blunted responses to vagal stimulation and methacholine were observed in trained rats.

    Conclusions:

    • Exercise training leads to significant impairments in vagal function in rats.
    • The observed resting bradycardia in trained rats is likely due to alterations in cardiac pacemaker cells, as evidenced by the reduced intrinsic HR.
    • These findings highlight a complex interplay between exercise, autonomic control, and cardiac function.