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Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

[Comparison of the influence of general and regional anesthesia on basic haemodynamic parameters during carotid

R Sindelić1, G Vlajković, L Davidović

  • 1Institut za anesteziju i reanimaciju KCentra Srbije, Beograd.

Acta Chirurgica Iugoslavica
|July 16, 2005
PubMed

Insights

Regional anesthesia (RA) offers superior hemodynamic stability during carotid endarterectomy (CEA) compared to general anesthesia (GA). RA showed no significant hemodynamic changes, making it a safer anesthetic choice for CEA patients.

Area of Science:

  • Anesthesiology
  • Neurosurgery
  • Cardiovascular Surgery

Background:

  • Carotid endarterectomy (CEA) is crucial for preventing stroke but carries significant perioperative risks.
  • Anesthetic techniques, including general anesthesia (GA) and regional anesthesia (RA) via cervical plexus block, aim to mitigate these risks.
  • Hemodynamic stability is paramount during CEA to minimize morbidity and mortality.

Purpose of the Study:

  • To compare hemodynamic changes during CEA under GA versus RA.
  • To evaluate the safety and efficacy of different anesthetic approaches for CEA.

Main Methods:

  • Fifty patients undergoing CEA were randomized into GA and RA groups.
  • Hemodynamic parameters (systolic, mean, diastolic blood pressure, heart rate, Rate-Pressure Product index) were monitored at six time points.
  • Data were collected before anesthesia, during surgery (including carotid clamping and declamping), and postoperatively.

Main Results:

  • Patients under GA experienced significant hemodynamic changes (blood pressure, RPP index) post-induction, attributed to thiopental.
  • These changes under GA remained within homeostatic limits.
  • No significant hemodynamic alterations were observed in patients receiving RA throughout the procedure.

Conclusions:

  • Regional anesthesia provides superior hemodynamic stability during carotid endarterectomy compared to general anesthesia.
  • RA is a hemodynamically safer anesthetic option for CEA patients.
  • Anesthetic choice significantly impacts perioperative outcomes in CEA.

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