Prostate cancer: chemoprevention update 2005

Related Experiment Video

Updated: Aug 17, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Neil Fleshner1, Rami Al Azab

  • 1Department of Surgery (Urology), University Health Network and University of Toronto, Toronto, Ontario, Canada.

The Canadian Journal of Urology
|July 16, 2005
PubMed
Abstract

Insights

Agents that slow prostate cancer growth show promise for prevention. While finasteride is the only proven agent, ongoing trials will clarify the roles of soy, vitamin E, and selenium in prostate cancer chemoprevention.

Area of Science:

  • Oncology
  • Urology
  • Preventive Medicine

Background:

  • Agents slowing prostate cancer cell growth may serve as adjuncts to standard treatments like surgery, radiation, or chemotherapy.
  • The potential for chemoprevention strategies in prostate cancer management is an active area of research.

Purpose of the Study:

  • To evaluate the efficacy of various agents in preventing prostate cancer.
  • To identify agents that can be used as chemoprevention strategies for prostate cancer.

Main Methods:

  • Review of existing evidence on prostate cancer chemoprevention.
  • Identification of agents with demonstrated effects on prostate cancer cell growth.
  • Highlighting ongoing randomized trials assessing chemoprevention agents.

Main Results:

  • Currently, only finasteride meets the criterion for Level-1 evidence in prostate cancer chemoprevention.
  • Several agents, including soy, vitamin E, and selenium, are under investigation.

Conclusions:

  • Effective chemoprevention strategies for prostate cancer hold significant promise.
  • Well-designed randomized trials are crucial for definitive evidence and are expected to yield results within 2 to 8 years.

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...