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Time since menopause does not affect plasma viscosity, plasma thromboxane levels and Doppler findings
Fulvia Mancini1, Nicola Persico, Giorgia Regnani
1Department of Obstetrics and Gynecology 'G. A. Galli', University of Bologna, Bologna, Italy.
Summary
Transdermal hormone replacement therapy (HRT) benefits women regardless of menopausal duration. This study found HRT improved cardiovascular markers like plasma viscosity and vascular impedance in all participants.
Area of Science:
- Endocrinology
- Cardiovascular Physiology
- Women's Health
Background:
- Hormone replacement therapy (HRT) is used to manage menopausal symptoms.
- The timing of HRT initiation relative to menopause onset may influence its effects.
- Understanding HRT's impact on vascular health is crucial for optimizing treatment.
Purpose of the Study:
- To investigate if the duration since menopause affects the hemodynamic benefits of transdermal HRT.
- To compare thromboxane B2 levels, plasma viscosity, and arterial Doppler parameters in women with different menopausal durations undergoing HRT.
Main Methods:
- Thirty-five postmenopausal women were divided into two groups based on time since menopause (<5 years vs. >5 years).
- Participants received continuous transdermal estradiol and cyclical medroxyprogesterone acetate for 6 months.
- Vascular parameters including plasma viscosity, thromboxane B2, and Doppler flow indices were measured at baseline and after treatment.
Main Results:
- Transdermal HRT significantly reduced plasma viscosity and thromboxane B2 levels in both groups.
- A significant reduction in vascular impedance was observed in uterine, carotid, ophthalmic, and bladder wall arteries post-treatment.
- No significant differences in treatment response were noted between women within 5 years of menopause versus those postmenopausal for longer.
Conclusions:
- The duration since menopause does not appear to influence the positive hemodynamic effects of transdermal HRT.
- Transdermal HRT offers consistent cardiovascular benefits, including improved vascular function, irrespective of menopausal timing in normal-weight women.