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Survey of hematological aspects of Gaucher disease

Ari Zimran1, Gheona Altarescu, Bernard Rudensky

  • 1Gaucher Clinic, Shaare Zedek Medical Center, P.O. Box 3235, Jerusalem 91031, Israel.

Hematology (Amsterdam, Netherlands)
|July 16, 2005
PubMed

Insights

Hematologists manage Gaucher disease (GD), a rare genetic disorder. This review examines changes and constants in hematological aspects of GD since targeted therapies became available.

Area of Science:

  • Hematology
  • Genetics
  • Rare Diseases

Background:

  • Gaucher disease (GD) is a lysosomal storage disorder with significant hematological manifestations.
  • Hematologists have traditionally managed patients with GD.
  • Therapeutic advances have become available in the last 15 years.

Purpose of the Study:

  • To review the evolution of hematological signs and symptoms in Gaucher disease.
  • To assess changes and constants in GD hematology since the advent of therapy.

Main Methods:

  • Literature review focusing on hematological aspects of Gaucher disease.
  • Analysis of studies published over the last 15 years.

Main Results:

  • The review highlights persistent hematological features of Gaucher disease.
  • It also identifies shifts in the presentation and management of these features post-therapy.

Conclusions:

  • Hematological expertise remains crucial for Gaucher disease management.
  • Understanding the dynamic nature of hematological signs is key for optimal patient care.

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