A privileged view of NKT cells and peripheral tolerance through the eye

The eye is an immune-privileged site that uses specialized mechanisms to protect itself from damage and to preserve its visual acuity. Among the mechanisms that contribute to the eye's privileged existence is its ability to induce both local and peripheral tolerance to antigens that may transgress its chambers. Experimentally, antigens that are inoculated into the anterior chamber induce an associated immune deviation of immune lymphocytes from their potential T-helper inflammatory responses to T regulatory cells. The prominent role of a somewhat rare cell called invariant (i)NKT cell in the process of tolerance induced through the anterior chamber-associated immune deviation model, ACAID, has revealed novel biological characteristics for the iNKT cell, as well as novel mechanisms for the induction of tolerance that have not been previously known or considered. The role of the iNKT cell in ACAID and its novel story is discussed in this mini-review.