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Updated: Aug 10, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
Studies on the drug release properties of nano-encapsulated indomethacin microparticles
Abstract:
Indomethacin micro-crystals sized approximately 2 microm have been encapsulated with polyelectrolyte multi-layers for the purpose of controlled release. Charged linear poly (dimethyldiallyl ammonium chloride) (PDDA) and poly (styrene sulphonate) (PSS) were alternatively deposited on approximately 2 microm drug micro-crystals. The release of indomethacin from coated micro-crystals was measured in aqueous solutions of pH 1.4 and 6.8. The polyelectrolyte multi-layer capsule thickness was proved to control. The results provided a method of achieving prolonged drug release through self-assembly of polymeric shells on drug microcrystals.
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