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Related Experiment Videos

Pulmonary function tests versus computed tomography in sheep with experimental emphysema.

Andrew Hoffman1, Larry Tsai, Melissa Mazan

  • 1Department of Clinical Sciences, Tufts University School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA. andrew.hoffman@tufts.edu

Experimental Lung Research
|July 16, 2005
PubMed
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Pulmonary function tests (PFTs) showed limited utility in detecting emphysema progression in sheep. However, expired reserve volume (ERV) and CT scans effectively identified changes, correlating with morphological alterations in this animal model.

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Animal Models

Background:

  • Emphysema is a progressive lung disease characterized by alveolar destruction.
  • Accurate assessment of emphysema progression is crucial for evaluating therapeutic interventions.
  • Animal models are vital for studying disease mechanisms and testing treatments.

Purpose of the Study:

  • To compare the effectiveness of pulmonary function tests (PFTs) and computed tomography (CT) in characterizing papain-induced emphysema in sheep.
  • To evaluate the sensitivity of different PFTs, including plethysmography, helium dilution, and expired reserve volume (ERV), in detecting emphysema progression.
  • To correlate functional lung changes with morphological alterations observed in an emphysema animal model.

Main Methods:

  • Twelve sheep were induced with papain to develop emphysema.

Related Experiment Videos

  • Pulmonary function tests were performed, including plethysmography (FRC(pleth)), helium dilution (FRC(He)), and expired reserve volume (ERV).
  • Computed tomography (CT) was used to assess lung volumes and air trapping.

    • Main Results:

    • FRC measured by plethysmography and helium dilution remained unchanged post-papain induction.
    • Expired reserve volume (ERV) significantly decreased, indicating increased residual volume (RV) and gas trapping (P = .02).
    • CT-measured functional residual capacity (FRC) increased in 10 out of 12 sheep (P = .008), consistent with emphysematous changes.

    Conclusions:

    • Standard plethysmography was insensitive to the progression of emphysema in this sheep model.
    • Expired reserve volume (ERV) and CT-derived FRC measurements demonstrated similar sensitivity to emphysema.
    • Both ERV and CT findings aligned with the expected morphological changes in papain-induced emphysema, suggesting their utility in this model.