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Updated: Aug 17, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine
Jairam Sastry1, Stewart J Kellie
1Oncology Unit, The Children's Hospital at Westmead, and Discipline of Paediatrics and Child Health at the University of Sydney, Sydney, NSW, Australia. jairamsastry@hotmail.com
Abstract:
Cisplatin in higher doses have been used routinely in the treatment of childhood tumours including neuroblastoma and germ cell tumors. Amifostine, a broad-spectrum cytoprotector of normal tissues, has been approved by U.S. Food and Drug Administration for use in patients receiving cisplatin. Such administration of amifostine has been reported to reduce cisplatin-related toxicities in some studies, but not all. The authors report a case of severe toxicity with cisplatin in a girl with epithelial cell carcinoma of the ovary despite the use of amifostine.
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