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Histological changes associated with mesotherapy for fat dissolution.

Paul T Rose¹, Michael Morgan

¹paultrose@yahoo.com

Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology

|July 16, 2005

Summary

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Mesotherapy using phosphatidylcholine/deoxycholate injections causes inflammation and fat cell death in subcutaneous fat. This histological study reveals the mechanism behind fat reduction from these popular cosmetic treatments.

Area of Science:

Dermatology
Histopathology
Cosmetic Science

Background:

Mesotherapy is a non-surgical cosmetic procedure popular for localized fat reduction.
Phosphatidylcholine/deoxycholate (PC/DC) injections are frequently used in mesotherapy.
Histological evidence explaining PC/DC's mechanism of action was lacking.

Observation:

Skin biopsies were taken one and two weeks post-PC/DC injection.
Biopsies revealed normal epidermis and dermis.
Subcutaneous fat showed mixed septal and lobular panniculitis.

Findings:

Fat lobules were infiltrated by lymphocytes and macrophages.
Macrophages included foam cells and multinucleated giant cells.
Inflammation was linked to serous atrophy and microcyst formation.

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Implications:

Mesotherapy with PC/DC impacts subcutaneous adipose tissue.
Fat reduction is theorized to result from inflammatory-mediated necrosis and resorption.
This study provides histological insight into mesotherapy's fat-dissolving effects.