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Is GST gene polymorphism a risk factor in developing exfoliation syndrome?
Ayça Yilmaz1, Lülüfer Tamer, Nurcan Aras Ates
1Ophthalmology Department, Mersin University Faculty of Medicine, Mersin, Turkey. aycayilmaz@mersin.edu.tr
Current Eye Research
|July 16, 2005
Summary
Glutathione S-transferase (GST) gene variations, including GSTM1, GSTP1, and GSTT1, were not found to be associated with exfoliation syndrome (XFS) or its related glaucoma. This study found no significant genetic links to XFS risk.
Area of Science:
- Genetics
- Ophthalmology
- Molecular Biology
Background:
- Exfoliation syndrome (XFS) is a common condition leading to secondary glaucoma.
- Glutathione S-transferases (GSTs) are crucial enzymes involved in detoxification.
- Genetic variations in GST genes (GSTM1, GSTP1, GSTT1) may influence susceptibility to various diseases.
Purpose of the Study:
- To investigate the distribution of GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with XFS.
- To determine if specific GST gene polymorphisms are associated with the risk of developing XFS.
- To explore potential links between GST gene polymorphisms and XFS with glaucoma or elevated intraocular pressure.
Main Methods:
- Real-time polymerase chain reaction (PCR) was used to detect GSTM1, GSTP1, and GSTT1 gene polymorphisms.
- The study included 60 patients diagnosed with XFS (including exfoliative glaucoma and XFS with elevated IOP) and 65 healthy controls.
- Genotype frequencies were compared between the XFS group and the control group.
Main Results:
- The prevalence of GSTM1 null and GSTP1 Ile/Val genotypes was slightly higher in the XFS group, but this difference was not statistically significant.
- No significant differences were observed in GSTT1 null and GSTP1 Val/Val polymorphisms between patients and controls.
- Increasing numbers of high-risk genotypes did not correlate with an increased risk of developing XFS (p = 0.73).
Conclusions:
- GSTM1, GSTP1, and GSTT1 gene polymorphisms do not appear to be significantly associated with the risk of developing exfoliation syndrome.
- The study suggests that these specific GST gene polymorphisms are unlikely to be major genetic factors in the pathogenesis of XFS or associated glaucoma.