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Cicatricial pemphigoid and dry eye
1Moorfields Eye Hospital, London, United Kingdom. j.dart@ucl.ac.uk
Seminars in Ophthalmology
|July 16, 2005
Summary
Cicatricial pemphigoid, an autoimmune disorder, affects the conjunctiva. Integrated management of ocular surface disease, inflammation, and dry eye is crucial for preserving vision.
Area of Science:
- Ophthalmology
- Immunodermatology
- Autoimmune Diseases
Background:
- Cicatricial pemphigoid is the most common immunobullous disorder causing conjunctival cicatrization.
- It's an autoimmune disease targeting the conjunctival basement membrane, typically bilateral and affecting females aged 30-90.
- Ocular complications, including tear deficiency and surface failure, can lead to vision loss.
Purpose of the Study:
- To outline the integrated management strategies for ocular cicatricial pemphigoid.
- To emphasize the importance of addressing dry eye, lid malposition, blepharitis, and conjunctival inflammation.
Main Methods:
- Management involves addressing lid/lash malposition with plastic surgery.
- Tetracyclines and lid hygiene manage associated blepharitis.
- Preservative-free lubricants and ointments manage dry eye; specialized contact lenses may improve vision.
Main Results:
- Integrated management addresses multiple facets of ocular cicatricial pemphigoid.
- Systemic immunosuppressive therapy is often required to control inflammation and prevent progression.
Conclusions:
- Effective management of ocular cicatricial pemphigoid requires a multidisciplinary approach.
- Controlling conjunctival inflammation is paramount to prevent disease progression and preserve vision.