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Related Experiment Videos

p37 Induces tumor invasiveness.

Catherine M Ketcham1, Satoshi Anai, Robbie Reutzel

  • 1Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, 32610, USA.

Molecular Cancer Therapeutics
|July 16, 2005
PubMed
Summary

Mycoplasma hyorhinis protein p37 correlates with human carcinomas and may promote cancer invasion and metastasis. Targeting p37 could be a novel therapeutic strategy for cancer treatment.

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Area of Science:

  • Microbiology
  • Oncology
  • Molecular Biology

Background:

  • A protein p37, encoded by Mycoplasma hyorhinis, has been detected in human carcinomas.
  • p37 is hypothesized to play a role in promoting cancer invasion and metastasis.

Purpose of the Study:

  • To investigate the role of Mycoplasma hyorhinis p37 in cancer cell invasiveness.
  • To explore the potential of p37 as a molecular target for cancer therapy.

Main Methods:

  • Recombinant p37 was used to treat prostate carcinoma and melanoma cell lines in vitro.
  • Cancer cell binding and invasiveness were assessed after p37 exposure.
  • Monoclonal antibodies against p37 were used to reverse p37 effects.
  • Sequence comparisons and molecular modeling were performed to identify similarities between p37 and other proteins.

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  • Neuraminidase treatment was used to assess the role of sialic acid in p37 binding.

    • Main Results:

    • Recombinant p37 dose-dependently enhanced the invasiveness of prostate carcinoma and melanoma cells.
    • p37 did not significantly affect tumor cell growth.
    • The effects of p37 on cell binding and invasiveness were reversible with anti-p37 antibodies.
    • p37 shares sequence similarity with influenza hemagglutinin A, a sialic acid-binding protein.
    • p37 binding to prostate carcinoma cells was partially dependent on sialic acid.

    Conclusions:

    • Mycoplasma hyorhinis infection may contribute to human tumor invasiveness through the p37 protein.
    • p37's mechanism of action involves sialic acid-dependent binding and enhanced cell invasion.
    • p37 represents a potential molecular target for developing new cancer therapies.