Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone loss in rats with aldosteronism.

Aliye L Runyan1, Vikram S Chhokar, Yao Sun

  • 1Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

The American Journal of the Medical Sciences
|July 16, 2005
PubMed
Summary

Aldosteronism causes increased calcium and magnesium excretion, leading to bone loss. Combining hydrochlorothiazide and spironolactone effectively preserves bone density and cation balance in aldosteronism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of sarco/endoplasmic reticulum Ca²⁺-ATPase 2 (SERCA2) reduces brain injury and improves cognitive function following ischemic stroke.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Effects of fasudil against photothrombotic stroke in genetically modified obese (ob/ob) mice.

Metabolic brain disease·2025
Same author

Key hepatoprotective roles of mitochondria in liver regeneration.

American journal of physiology. Gastrointestinal and liver physiology·2023
Same author

Mitochondrial Role in Oncogenesis and Potential Chemotherapeutic Strategy of Mitochondrial Infusion in Breast Cancer.

International journal of molecular sciences·2022
Same author

Regulation of endothelial nitric oxide synthase in cardiac remodeling.

International journal of cardiology·2022
Same author

20<i>S</i>-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis.

Frontiers in immunology·2021

Area of Science:

  • Endocrinology
  • Nephrology
  • Bone Metabolism

Background:

  • Aldosteronism is associated with mineral imbalances and potential bone loss.
  • Hypercalciuria and hypermagnesuria are proposed mechanisms contributing to bone resorption in aldosteronism.

Purpose of the Study:

  • To investigate the effects of aldosteronism on urinary calcium and magnesium excretion and bone mineral density.
  • To determine if hydrochlorothiazide and spironolactone can mitigate these effects.

Main Methods:

  • Animal model of aldosteronism (ALDOST) with concurrent salt loading.
  • Treatment groups included controls, hydrochlorothiazide, and hydrochlorothiazide plus spironolactone.
  • Measurements included 24-hour urinary calcium and magnesium, plasma electrolytes, parathyroid hormone, and femur bone mineral density.

Related Experiment Videos

Main Results:

  • Aldosteronism significantly increased urinary calcium and magnesium excretion, reduced plasma calcium, and decreased bone mineral density.
  • Hydrochlorothiazide alone attenuated hypercalciuria but not hypermagnesuria and did not fully prevent bone loss.
  • The combination of hydrochlorothiazide and spironolactone normalized urinary calcium, reduced magnesium excretion, prevented hypokalemia, and preserved bone mineral density.

Conclusions:

  • Hypercalciuria and hypermagnesuria in aldosteronism contribute to bone loss via secondary hyperparathyroidism.
  • Hydrochlorothiazide alone offers partial protection against bone loss.
  • The combination of hydrochlorothiazide and spironolactone is superior in maintaining mineral homeostasis and bone integrity in aldosteronism.