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Related Experiment Videos

Intercellular adhesion molecule-1 and childhood asthma.

Yu-Fen Li1, Yo-Hsuang Tsao, W James Gauderman

  • 1Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CHP 236, Los Angeles, CA 90033, USA.

Human Genetics
|July 16, 2005
PubMed
Summary

Genetic variations in intercellular adhesion molecule-1 (ICAM-1) influence childhood asthma risk differently across ethnic groups. Specific ICAM-1 variants and haplotypes show protective effects in some populations while increasing risk in others.

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Area of Science:

  • Genetics
  • Immunology
  • Pediatrics

Background:

  • Childhood asthma is a complex respiratory disease with genetic and environmental components.
  • Intercellular adhesion molecule-1 (ICAM-1) plays a role in immune responses and inflammation, relevant to asthma pathogenesis.
  • Genetic variants in ICAM-1 may influence asthma susceptibility and severity.

Purpose of the Study:

  • To investigate the association between functional variants in ICAM-1 and childhood asthma.
  • To examine how these associations differ across ethnic groups (African-Americans, Hispanic whites, non-Hispanic whites).
  • To assess the impact of population stratification on observed genetic associations.

Main Methods:

  • Examined functional variants at codons 29, 241, and 469 of ICAM-1 in Children's Health Study participants.

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  • Conducted association analyses stratified by ethnicity.
  • Utilized an independent family-based sample to evaluate population stratification.
  • Analyzed common ICAM-1 haplotypes and their association with asthma risk.

    • Main Results:

    • Among African-Americans, ICAM-1 variant 469G showed a lower risk for asthma, while variant 29T increased risk for early onset active asthma.
    • Protective associations of the 241A allele were observed in non-Hispanic and Hispanic whites for both ever asthma and early onset active asthma.
    • Haplotype analyses revealed that the AAG haplotype was associated with reduced asthma risk in Hispanics and non-Hispanic whites, while the AGG haplotype showed protective effects in African-Americans.

    Conclusions:

    • Functional variants and haplotypes of ICAM-1 are associated with childhood asthma risk, with ethnic-specific effects.
    • The 241A and 469G variants, as part of certain haplotypes, may confer reduced asthma risk.
    • Findings suggest ICAM-1 genetic variations are important factors in childhood asthma etiology across diverse populations.