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Systemic interleukin-10 concentrations do not alter between the first and second trimester in normal pregnancy
R M F van der Weiden1, J W Janssen, M Stegeman
1Department of Obstetrics and Gynecology, Sint Franciscus Gasthuis, Kleiweg 500, 3045, Rotterdam, The Netherlands. rmfvdwei@knmg.nl
Archives of Gynecology and Obstetrics
|July 16, 2005
Summary
Systemic levels of Interleukin 10 (IL-10) do not significantly change between the first and second trimesters of normal pregnancy. This suggests IL-10 is not systemically activated during early gestation.
Area of Science:
- Immunology
- Reproductive Biology
- Maternal-Fetal Medicine
Background:
- Interleukin 10 (IL-10) plays a role in normal fertility.
- Changes in systemic IL-10 during pregnancy may indicate immune system shifts at the maternal-fetal interface.
Purpose of the Study:
- To investigate systemic changes in serum IL-10 levels during early gestation.
- To determine if IL-10 is systemically activated between the first and second trimesters of uncomplicated pregnancy.
Main Methods:
- Serum IL-10 concentrations were measured in 32 women during their first and second trimesters.
- A sensitive assay capable of detecting IL-10 levels between 0.50 pg/ml and 4.0 pg/ml was utilized.
Main Results:
- No statistically significant difference was observed in serum IL-10 levels between the first trimester (median 1.10 pg/ml) and the second trimester (median 1.05 pg/ml).
- The range of IL-10 levels in the first trimester was 0.53-4.60 pg/ml, and in the second trimester was 0.64-3.30 pg/ml.
Conclusions:
- Interleukin 10 (IL-10) does not show systemic activation detectable by this assay between the first and second trimesters of normal pregnancy.
- These findings indicate a stable IL-10 profile in early, uncomplicated gestation.