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alpha(v)beta(3) Integrin in central nervous system tumors.

Michael Lim1, Samira Guccione, Terri Haddix

  • 1Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA. mklim@stanford.edu

Human Pathology
|July 16, 2005
PubMed
Summary

Alpha(v)beta(3) integrin is highly expressed in vestibular schwannomas and ependymomas, suggesting a role in angiogenesis. Other central nervous system tumors show variable expression, indicating potential therapeutic targets.

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Area of Science:

  • Neuro-oncology
  • Vascular Biology
  • Integrin Signaling

Background:

  • Integrins, such as alpha(v)beta(3), are crucial for angiogenesis, the formation of new blood vessels.
  • Angiogenesis plays a significant role in the growth and progression of central nervous system (CNS) tumors.
  • Alpha(v)beta(3) integrin is a potential therapeutic target for antiangiogenic strategies in CNS neoplasms.

Purpose of the Study:

  • To investigate and compare the expression levels of alpha(v)beta(3) integrin in various primary CNS tumors.
  • To assess the potential correlation between alpha(v)beta(3) integrin expression and tumor type, specifically in ependymomas, oligodendrogliomas, pilocytic astrocytomas, medulloblastomas, and vestibular schwannomas.

Main Methods:

  • Surgical harvesting and freezing of 5 samples each of 5 distinct CNS tumor types.

Related Experiment Videos

  • Pathological diagnosis confirmation followed by immunohistochemistry using an anti-alpha(v)beta(3) monoclonal antibody (LM609).
  • Quantitative assessment of alpha(v)beta(3) expression using a 0-3 grading scale based on the percentage of positively stained vessels.

    • Main Results:

    • All vestibular schwannomas exhibited strong (grade 3) alpha(v)beta(3) expression, particularly in Antoni B regions.
    • Four out of five ependymomas also showed uniformly strong (grade 3) alpha(v)beta(3) expression.
    • Oligodendrogliomas, medulloblastomas, and pilocytic astrocytomas displayed variable and generally moderate alpha(v)beta(3) expression, despite high vascular density.

    Conclusions:

    • Alpha(v)beta(3) integrin expression is prominent in vestibular schwannomas and ependymomas, suggesting a significant contribution to their angiogenesis.
    • The variable expression in oligodendrogliomas, medulloblastomas, and pilocytic astrocytomas may indicate temporal or regional differences in angiogenesis within these tumors.
    • This study is the first to report alpha(v)beta(3) integrin expression in vestibular schwannomas, medulloblastomas, and pilocytic astrocytomas, highlighting its potential as a therapeutic target.