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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
Synthesis of water-soluble, multiple functionalizable dendrons for the conversion of large dendrimers or other
Stephan Müller1, A Dieter Schlüter
1Institut für Chemie/Organische Chemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
Abstract:
The synthesis of dendrons and dendrimers which carry OEG chains and bidentate ligands and/or fluorescence tags is described. The orthogonally protected functional groups of the dendrons allow modification of the substitution pattern and attachment to larger entities. Both dendrons and dendrimers are highly water-soluble. The dendrons should have considerable potential to convert, for example, commercially available, high-generation dendrimers into water-soluble, versatile support materials for antitumor therapy.
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