Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

White matter hyperintensities and depression--preliminary results from the LADIS study.

Michael J Firbank1, John T O'Brien, Sanjeet Pakrasi

  • 1Institute for Ageing and Health, University of Newcastle upon Tyne, UK.

International Journal of Geriatric Psychiatry
|July 16, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial for cerebral circulation cognition & behavior special issue on brain health.

Cerebral circulation - cognition and behavior·2026
Same author

Machine learning prediction of dementia conversion in mild cognitive impairment: A two- to six-year follow-up study.

Journal of the International Neuropsychological Society : JINS·2026
Same author

The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia-The VasCog-2-WSO Criteria.

JAMA neurology·2025
Same author

Depressive Symptoms and Amyloid Pathology.

JAMA psychiatry·2025
Same author

Editorial. <i>CCCB</i>: The journal at age 5.

Cerebral circulation - cognition and behavior·2024

White matter hyperintensities (WMH) are linked to increased depressive symptoms in older adults. This association persists even when considering quality of life, suggesting WMH contributes to depression.

Area of Science:

  • Neuroimaging
  • Geriatric Psychiatry
  • Public Health

Background:

  • White matter hyperintensities (WMH) are implicated in late-life depression.
  • The precise mechanisms linking WMH to depression remain unclear.

Purpose of the Study:

  • To investigate the relationship between WMH, depressive symptoms, and quality of life in older adults.
  • To explore WMH as a potential factor in the development of depression.

Main Methods:

  • A pan-European multicentre study involving 629 older subjects.
  • Assessment of white matter hyperintensities (WMH) using MRI and a three-point scale.
  • Evaluation of depressive symptoms (Geriatric Depression Scale) and quality of life (Euro-QOL).

Main Results:

Related Experiment Videos

  • Depressive symptoms correlated significantly with WMH ratings (Spearman's rho = 0.11, p = 0.008).
  • Quality of life strongly predicted depressive symptoms (p < 0.001).
  • Severe WMH were associated with increased depression (p = 0.028), independent of quality of life.

Conclusions:

  • White matter hyperintensities (WMH) appear to contribute to increased depressive symptoms in older individuals.
  • WMH may play a direct role in depression, not solely mediated by quality of life.