Related Experiment Video
Updated: Aug 17, 2026
OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
Published on: May 9, 2021
A prospective, randomized and blinded comparison between 10,000 IU urinary and 250 microg recombinant human chorionic
Vicente Abdelmassih1, Flavio G Oliveira, Sergio P Goncalves
1Clinica e Centro de Pesquisa em Reprodução Humana Roger Abdelmassih, Av. Brasil, 1085, São Paulo, SP, CEP. clinicavida@terra.com.br
Purpose:
To compare the efficacy and safety of u-hCG with r-hCG in IVF cycles.
Methods:
A prospective, investigator-blind, randomized, comparative study. Patients (n = 100) < or =35 years with IVF indication were randomly assigned on the day of hCG administration for oocyte maturation to receive either u-hCG (10,000 IU) or r-hCG (250 microg).
Results:
No statistical differences were found between groups in relation to total number of oocytes retrieved, percentage of mature oocytes, number of injected oocytes, fertilization rates and number of embryos transferred. The data indicate a possible trend toward a higher incidence of pregnancy in the r-hCG group. Adverse events, predominantly injection-site reactions, were significantly more common in the u-hCG group.
Conclusions:
r-hCG is at least as effective for inducing final stages of oocyte maturation as 10,000 IU u-hCG and is also associated with significantly better patient tolerance and thus higher patient acceptability.
