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Published on: July 19, 2018

Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients

Sevcan A Bakkaloglu1, Necla Buyan, Tohru Funahashi

  • 1Department of Pediatric Nephrology, Gazi University, Ankara, Turkey. sevcan@gazi.edu.tr

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|July 19, 2005
PubMed

Insights

In pediatric patients on chronic peritoneal dialysis (CPD), serum adiponectin (ADPN) levels were inversely associated with creatinine. This suggests ADPN may be a novel prognostic marker for cardiovascular risk in these children.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Risk Assessment
  • Renal Disease Biomarkers

Background:

  • Atherosclerotic vascular diseases are a leading cause of mortality in pediatric end-stage renal disease (ESRD) patients undergoing chronic peritoneal dialysis (CPD).
  • Adiponectin (ADPN), an anti-atherogenic protein, is elevated in ESRD, but low levels are linked to cardiovascular death.
  • The role of ADPN in pediatric CPD patients requires further clarification.

Purpose of the Study:

  • To investigate atherosclerotic risk factors in children on CPD.
  • To determine the significance of serum adiponectin (ADPN) levels in pediatric CPD patients.

Main Methods:

  • A cross-sectional study was conducted in a university hospital's pediatric peritoneal dialysis unit.
  • 18 children on CPD and 20 healthy controls were assessed for serum ADPN, blood pressure, glucose, lipids, apolipoprotein B, C-reactive protein (CRP), lipoprotein(a), and homocysteine.
  • Statistical analysis correlated ADPN levels with clinical parameters.

Main Results:

  • Serum ADPN levels were significantly higher (threefold) in pediatric CPD patients compared to controls.
  • Apolipoprotein B and CRP levels were also elevated in the CPD group.
  • A significant negative correlation was observed between log ADPN and creatinine levels (r = -0.54, p < 0.05) in CPD patients.

Conclusions:

  • Serum ADPN levels are inversely associated with creatinine in pediatric CPD patients.
  • ADPN may serve as a novel predictive marker for prognosis in pediatric patients with ESRD on CPD.
  • Further research is warranted to validate ADPN as a biomarker for cardiovascular risk in this population.
Abstract

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