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Application of pharmaceutical profiling assays for optimization of drug-like properties
1Wyeth Inc, 865 Ridge Road, Monmouth Junction, NJ 08852, USA. dil@wyeth.com
Abstract:
Pharmaceutical profiling assays provide an early assessment of drug-like properties, such as solubility, permeability, metabolism, stability and drug-drug interactions. This information can be used to alert project teams to potential property issues, predict and diagnose in vivo assay results, guide structure-property relationships, provide insight into structure modification, and help drug discovery teams to make informed decisions. Successful drugs can be developed when biological activities of interest and pharmaceutical properties are optimized in parallel.
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