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Updated: Aug 17, 2026
An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
Long-term evaluation of laser-treated silicone (LTS) membrane as a pericardial substitute: in vivo study
Saeid Amanpour1, Hosein Ahamadi, Hamid Mirzadeh
1Experimental Medicine Laboratory, Cancer Institute, Tehran University of Medical Science, Tehran, Iran.
Objective:
The purpose of this study was prevention of adhesion formation in reoperative cardiac surgery using laser-treated silicone (LTS) membrane as a new pericardial substitute in the sheep model.
Methods:
Thirty ewes (35-45 kg) were used and categorized into two groups including test and control groups. In test group (n = 18), the pericardium was excised, and the LTS membrane was implanted as a pericardial substitute. In the control group (n = 12), the pericardium was excised without LTS membrane implantation. During follow-up ranging from 3 to 28 months, animals were observed for any clinical sign of postoperative problems. Thirty reoperations were performed in both test and control groups to evaluate adhesion formation.
Results:
In the control group, dense adhesions were observed, while in the study group adhesion formation was reduced at all sites covered by LTS membrane (p < 0.03), and no infection or other complications were observed.
Conclusions:
The LTS membrane is safe and efficacious in the reduction of pericardial adhesion formation and might be used in patients undergoing cardiac surgery who need reoperation.
