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Related Experiment Videos

Bioengineered tissues: the science, the technology, and the industry.

T Ahsan1, R M Nerem

  • 1Georgia Tech/Emory Center for the Engineering of Living Tissues, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332-0363, USA.

Orthodontics & Craniofacial Research
|July 19, 2005
PubMed
Summary

Tissue engineering and regenerative medicine aim to repair or replace tissues and organs. Key challenges include cell sourcing, fabrication, immune acceptance, manufacturing scale-up, and product preservation for clinical application.

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Tissue engineering: from basic science to products: a preface.

Tissue engineering·2009

Area of Science:

  • Bioengineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Emerging fields focused on repairing, replacing, or regenerating tissues and organs.
  • Growing as a science, technology, and industry with significant public health potential.

Purpose of the Study:

  • Identify and discuss major challenges in tissue engineering and regenerative medicine.
  • Highlight critical issues hindering clinical translation and widespread application.

Main Methods:

  • Discussion of key issues in tissue engineering and regenerative medicine.
  • Analysis of challenges related to cell sourcing, fabrication, and immune acceptance.

Main Results:

  • Critical issues include cell source, tissue/organ fabrication, and immune acceptance.

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  • Technological hurdles involve manufacturing scale-up and preservation of cell products.
  • Opportunities lie in addressing chronic diseases, organ transplantation needs, and neural repair.

    • Conclusions:

    • Translating regenerative medicine from benchtop to bedside requires collaboration between scientists, industry, and government.
    • Addressing grand challenges is essential for advancing the field and patient care.