Related Experiment Video
Updated: Aug 10, 2026
Synthesis of an Intein-mediated Artificial Protein Hydrogel
Published on: January 27, 2014
Advances in skeletal tissue engineering with hydrogels
1Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA. jhe@bme.jhu.edu
Objectives:
Tissue engineering has the potential to make a significant impact on improving tissue repair in the craniofacial system. The general strategy for tissue engineering includes seeding cells on a biomaterial scaffold. The number of scaffold and cell choices for tissue engineering systems is continually increasing and will be reviewed.
Design:
Multilayered hydrogel systems were developed to coculture different cell types and develop osteochondral tissues for applications including the temporomandibular joint.
Experimental Variable:
Hydrogels are one form of scaffold that can be applied to cartilage and bone repair using fully differentiated cells, adult and embryonic stem cells.
Outcome Measure:
Case studies represent an overview of our laboratory's investigations.
Results:
Bilayered scaffolds to promote tissue development and the formation of more complex osteochondral tissues were developed and proved to be effective.
Conclusion:
Tissue engineering provides a venue to investigate tissue development of mutant or diseased cells and potential therapeutics.
