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Related Experiment Videos

A new variant of blepharospasm.

J S Elston1

  • 1National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|May 1, 1992
PubMed
Summary

This study investigates a specific eye opening disorder in ten patients. Findings suggest it may be a blepharospasm variant caused by abnormal muscle contractions.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Movement Disorders

Background:

  • Patients unable to initiate or sustain eye opening without overt orbicularis oculi spasm present a diagnostic challenge.
  • This condition can be isolated or associated with neurodegenerative diseases like Parkinson's disease and progressive supranuclear palsy.

Purpose of the Study:

  • To investigate the clinical features and underlying mechanisms of isolated and disease-associated eye opening difficulties.
  • To determine if this condition represents a distinct clinical entity or a variant of known disorders.

Main Methods:

  • Clinical assessment of ten patients with eye opening difficulties.
  • Electrophysiological investigations to evaluate muscle activity.
  • Review of patient history, including associated neurological conditions.

Main Results:

  • Five patients presented with an isolated eye opening disorder.
  • Three patients had Parkinson's disease and two had progressive supranuclear palsy, with eye opening difficulty developing 1-6 years after initial diagnosis.
  • Clinical and electrophysiological findings pointed towards abnormal contraction in the pre-tarsal orbicularis oculi.

Conclusions:

  • The investigated eye opening disorder appears to be a variant of blepharospasm.
  • Abnormal contractions in the pre-tarsal orbicularis oculi muscles are implicated in the pathophysiology.
  • Further research is warranted to fully characterize this condition and its management.

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