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Particle Templated Emulsification enables Microfluidic-Free Droplet Assays
Published on: March 9, 2021
The development and characterisation of triglyceride-based 'spontaneous' multiple emulsions
Manisha J Devani1, Marianne Ashford, Duncan Q M Craig
1GlaxoSmithKline, Park Road, Ware, Hertfordshire SG12 0DP, UK.
International Journal of Pharmaceutics
|July 19, 2005
Summary
Spontaneous formation of multiple emulsion droplets is possible using specific oils and Tween 80, offering several days of stability. Droplet breakdown varies with oil type and environment, influenced by lipolysis and pH.
Area of Science:
- Physical Chemistry
- Colloid Science
- Pharmaceutical Sciences
Background:
- Multiple emulsions offer advantages in drug delivery and formulation.
- Investigating novel methods for stable multiple emulsion formation is crucial.
Purpose of the Study:
- To investigate the one-step formation of multiple emulsion droplets using Labrafil M 1944 CS and Labrafac Lipophile WL 1349.
- To characterize droplet properties, stability, and lipolysis in aqueous media.
Main Methods:
- One-step emulsification with minimal agitation.
- Analysis of droplet size distribution and stability.
- Lipolysis studies using pancreatic lipase.
Main Results:
- Multiple emulsion droplets formed from both oils, with or without Tween 80.
- Optimal stability (several days) achieved with 10% Tween 80.
- Droplet breakdown accelerated in simulated intestinal fluid and high pH; lipolysis slowed by pegylation and surfactant.
Conclusions:
- 'Spontaneous' multiple emulsion formation is feasible.
- Stability is dependent on oil composition, media, and surfactant presence.
- Understanding droplet behavior is key for formulation development.
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