Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and complement regulators in the male reproductive system.

Claire L Harris1, Masashi Mizuno, B Paul Morgan

  • 1Complement Biology Group, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Health park, Cardiff CF 14 4XN, UK.

Molecular Immunology
|July 19, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysregulation of complement at the synapse in P301S mice and human tauopathies.

Acta neuropathologica communications·2026
Same author

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID.

Immunology·2026
Same author

Absence of complement terminal pathway activity in C6-deficient mice prolongs survival in a mouse model of severe malarial infection.

Immunobiology·2025
Same author

CD59, Disulphide-Locked Human C9 and Horse C9 Inhibit Human Membrane Attack Complex Assembly by Similar Mechanisms.

Immunology·2025
Same author

Complement dysregulation in human tauopathies.

Brain pathology (Zurich, Switzerland)·2025
Same author

Plasma complement system markers and their association with cardiometabolic risk factors: an ethnic comparison of White European and Black African men.

American journal of physiology. Endocrinology and metabolism·2025
Same journal

m6A modification of LINC00458 enhances HMOX1 stability via ELAVL1 recruitment to promote ferroptosis and aggravate asthma.

Molecular immunology·2026
Same journal

Overexpression of Hes1 inhibits cigarette smoke-induced mitochondrial apoptosis in AT2 cells by activating the Pgc-1α/Tfam signaling pathway.

Molecular immunology·2026
Same journal

Progesterone promotes favorable pregnancy outcomes in recurrent spontaneous, abortion by attenuating NK Cell overactivation and upregulating the cAMP/PKA/CREB signaling axis.

Molecular immunology·2026
Same journal

Oleanolic acid alleviates hepatic fibrosis by inhibiting liver macrophage recruitment and polarization.

Molecular immunology·2026
Same journal

Cordycepin attenuates diabetic nephropathy by dual-pathway activation of TFEB to restore autophagy and ameliorate podocyte injury.

Molecular immunology·2026
Same journal

Endothelial-derived TWEAK drives granulosa cell apoptosis in PCOS via the Fn14-oxidative stress axis.

Molecular immunology·2026
See all related articles

Spermatozoa use complement regulators to evade immune attack in the female reproductive tract, ensuring successful fertilization. These regulators also aid in sperm development and oocyte binding, impacting male fertility.

Area of Science:

  • Reproductive immunology
  • Cellular and molecular biology
  • Innate immunity

Background:

  • Spermatozoa must overcome innate immune defenses, particularly complement, in the female genital tract to achieve fertilization.
  • Complement is a key component of innate immunity present in the female reproductive tract, posing a significant challenge to sperm survival.

Purpose of the Study:

  • To explore the role of complement and its regulators in sperm survival, oocyte interaction, and fertility.
  • To investigate the unique distribution patterns of complement regulators on spermatozoa and their functional implications.

Main Methods:

  • Review of existing literature on complement system and spermatozoa.
  • Analysis of the distribution and function of complement regulatory proteins on sperm surface and in seminal plasma.

Related Experiment Videos

Main Results:

  • Complement evasion is crucial for sperm to reach the oocyte, facilitated by complement regulators in seminal plasma and on sperm.
  • Specific distribution patterns of complement regulators on spermatozoa suggest roles in sperm development and oocyte binding.
  • Complement regulators are implicated in clearing excess sperm and aiding sperm activation for oocyte engagement.

Conclusions:

  • Complement regulators are essential for sperm survival, function, and fertility by mediating immune evasion and facilitating key reproductive processes.
  • Understanding these roles is vital for diagnosing and treating male infertility.