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Correlation of bispectral index with end-tidal sevoflurane concentration and age in infants and children

H S Kim1, A Y Oh, C S Kim

  • 1Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.

British Journal of Anaesthesia
|July 19, 2005
PubMed

Insights

The bispectral index (BIS) showed a paradoxical increase with higher sevoflurane concentrations in children. Age significantly impacted BIS values, indicating its unreliability for measuring anaesthesia depth in pediatric patients.

Area of Science:

  • Anesthesiology
  • Pediatric Anesthesia
  • Neurophysiology

Background:

  • The bispectral index (BIS) is used to monitor anesthesia depth.
  • Its application in pediatric patients remains controversial.
  • This study investigates BIS correlation with sevoflurane and age in children.

Purpose of the Study:

  • To evaluate the correlation between the bispectral index (BIS) and end-tidal sevoflurane concentration (ET(sevo)).
  • To assess the influence of age on BIS values in infants and children.
  • To determine the reliability of BIS for monitoring anesthesia depth in pediatric populations.

Main Methods:

  • Eighty-one pediatric patients (6 months to 12 years) undergoing urology surgery were studied.
  • Sevoflurane was administered to achieve ET(sevo) of 2.0%, 3.0%, and 4.0%.
  • BIS (version XP) was continuously monitored across three age groups.

Main Results:

  • BIS decreased significantly as ET(sevo) rose from 2.0% to 3.0%.
  • A paradoxical increase in BIS was observed when ET(sevo) increased from 3.0% to 4.0%.
  • Non-linear regression revealed a significant correlation between BIS and age, with younger children exhibiting higher BIS values.

Conclusions:

  • BIS demonstrated a paradoxical increase with rising ET(sevo) (3.0% to 4.0%) in children aged 6 months to 12 years.
  • Significant variations in BIS values were noted at consistent ET(sevo) levels.
  • Age was identified as a key factor influencing BIS readings in this pediatric cohort.
Abstract

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