Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RNA meets chromatin.

Emily Bernstein1, C David Allis

  • 1Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA.

Genes & Development
|July 19, 2005
PubMed
Summary
This summary is machine-generated.

Noncoding RNAs and chromatin are newly intersecting fields. This review explores their roles in epigenetic processes like gene silencing and DNA elimination, suggesting RNA-binding proteins as a key link.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term maintenance of H3K27me3 in postmitotic neurons is dispensable for gene expression regulation.

bioRxiv : the preprint server for biology·2026
Same author

The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity.

Genes & development·2026
Same author

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.

Cancer discovery·2025
Same author

Loss of histone macroH2A1.1 causes kidney abnormalities secondary to a change in nutrient metabolization.

Science advances·2025
Same author

SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target.

Cell death & disease·2025
Same author

A needed nomenclature for nucleosomes.

Molecular cell·2025
Same journal

Corrigendum: Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

Genes & development·2026
Same journal

A new perspective on ATR's role in translesion synthesis.

Genes & development·2026
Same journal

Mechanisms coordinating exit from the stem cell state in mammals.

Genes & development·2026
Same journal

Evolutionarily conserved spliceosome-exosome pathway in nuclear mRNA surveillance.

Genes & development·2026
Same journal

CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning.

Genes & development·2026
Same journal

Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR.

Genes & development·2026
See all related articles

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Genomics

Background:

  • The fields of RNA and chromatin biology are increasingly recognized as interconnected.
  • Recent evidence highlights the significant implications of this intersection for understanding epigenetic regulation.

Purpose of the Study:

  • To review the implications of noncoding RNAs in the formation of specialized chromatin domains.
  • To discuss the role of RNA in diverse epigenetic processes, including dosage compensation, RNA interference-mediated heterochromatin assembly, gene silencing, and programmed DNA elimination.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of evidence from model organisms across eukaryotic kingdoms.

Main Results:

Related Experiment Videos

  • Noncoding RNAs are implicated in the establishment of specialized chromatin domains.
  • RNA plays a role in various epigenetic mechanisms, such as gene silencing and DNA elimination.
  • Similarities in machinery and design are observed across different eukaryotic kingdoms.

Conclusions:

  • The connection between RNA and chromatin is crucial for epigenetic regulation.
  • RNA-binding chromatin-associated proteins are proposed as a potential mechanistic link.
  • Further research is needed to elucidate the precise molecular mechanisms connecting RNA and chromatin.