Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The case for progesterone.

Donald G Stein1

  • 1Department of Emergency Medicine, Emory University School of Medicine, 1648 Pierce Dr., NE, Evans Bldg. Rm. 261, Atlanta, GA 30322, USA. dstei04@emory.edu

Annals of the New York Academy of Sciences
|July 19, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prophylactic progesterone prevents adverse behavioural and neurocognitive effects of neonatal anaesthesia exposure in rat.

British journal of anaesthesia·2021
Same author

Response to Korley et al.: Progesterone Treatment Does Not Decrease Serum Levels of Biomarkers of Glial and Neuronal Cell Injury in Moderate and Severe TBI Subjects: A Secondary Analysis of the Progesterone for Traumatic Brain Injury, Experimental Clinical Treatment (ProTECT) III Trial (DOI: 10.1089/neu.2020.7072).

Journal of neurotrauma·2021
Same author

Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells.

Molecular neurobiology·2021
Same author

Neurocognitive Outcomes in a Cisternal Blood Injection Murine Model of Subarachnoid Hemorrhage.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2020
Same author

Stroke-Induced Peripheral Immune Dysfunction in Vitamin D-Deficient Conditions: Modulation by Progesterone and Vitamin D.

Molecular neurobiology·2020
Same author

Visual recovery following optic nerve crush in male and female wild-type and TRIF-deficient mice.

Restorative neurology and neuroscience·2020
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Hormone therapy using natural progesterone, not synthetic versions, may offer neuroprotective benefits. This approach could potentially mitigate age-related cognitive and motor decline in both men and women.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • Recent hormone therapy (HT) trials for menopausal women yielded disappointing results due to increased health risks associated with synthetic compounds.
  • Existing research has predominantly focused on estrogens, overlooking the neurotrophic potential of progesterone.

Purpose of the Study:

  • To review the neurotrophic properties of progesterone.
  • To discuss the potential of progesterone in mitigating neurodegenerative and traumatic injuries.
  • To advocate for reconsidering progesterone in hormone therapy for its neuroprotective effects.

Main Methods:

  • Literature review of studies on hormone therapy and progesterone's effects on the central nervous system.
  • Analysis of clinical trial data concerning synthetic vs. natural hormone compounds.

Related Experiment Videos

  • Synthesis of evidence on progesterone's role in neuroprotection and repair.

    • Main Results:

    • Synthetic hormone combinations (conjugated equine estrogens with medroxyprogesterone acetate) are linked to increased health risks.
    • Progesterone possesses significant neurotrophic properties beneficial for central nervous system repair.
    • 17beta-estradiol combined with natural progesterone may offer a different risk-benefit profile than synthetic alternatives.

    Conclusions:

    • Progesterone warrants greater attention as a neurotrophic agent in hormone therapy.
    • This hormone may play a crucial role in preventing or reducing motor, cognitive, and sensory impairments associated with aging.
    • Future HT research should explore natural progesterone for its potential neuroprotective and restorative capabilities.