Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multifocal ERG in ethambutol associated visual loss.

R S Behbehani1, E L Affel, R C Sergott

  • 1Neuro-ophthalmology Service, Wills Eye Hospital, 840 Walnut Street, Philadelphia, PA 19107, USA. r_behbehani@hotmail.com

The British Journal of Ophthalmology
|July 19, 2005
PubMed
Summary

Ethambutol may cause retinal toxicity, not just optic nerve damage. Multifocal electroretinography (mERG) can detect these visual pathway changes in patients experiencing ethambutol-associated visual loss.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primer on visual field testing, electroretinography, and other visual assessments for patients treated with vigabatrin.

Acta neurologica Scandinavica. Supplementum·2011
Same author

Understanding and interpreting vision safety issues with vigabatrin therapy.

Acta neurologica Scandinavica. Supplementum·2011
Same author

Color Doppler imaging in glaucoma patients with asymmetric optic cups.

Journal of glaucoma·2009
Same author

Test/Retest reproducibility of color Doppler imaging assessment of blood flow velocity in orbital vessels.

Journal of glaucoma·2009
Same author

Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis.

Arthritis and rheumatism·2008
Same author

Anterior ischaemic optic neuropathy after rotator cuff surgery.

The British journal of ophthalmology·2006

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Toxicology

Background:

  • Ethambutol is a first-line medication for tuberculosis.
  • Ethambutol is known to cause optic neuropathy, leading to visual loss.
  • The precise anatomical site and extent of visual pathway dysfunction are not fully understood.

Observation:

  • A comparative case series involving four patients with ethambutol-associated visual loss.
  • Patients underwent multifocal electroretinography (mERG) to assess retinal function.
  • Two patients had advanced visual loss, and two had early signs of toxicity.

Findings:

  • Multifocal electroretinography (mERG) revealed abnormalities in ethambutol-treated patients.
  • A significant reduction in N1 amplitude was observed in the ethambutol group compared to controls.

Related Experiment Videos

  • These findings suggest retinal involvement in ethambutol-associated visual loss.

    • Implications:

    • Ethambutol may exert toxicity on the retina, in addition to the optic nerve.
    • Multifocal electroretinography (mERG) shows potential as a diagnostic and monitoring tool for ethambutol toxicity.
    • Early detection and monitoring can help manage ethambutol-induced visual impairment.