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Symptoms and pathophysiological correlations in patients with constipation and functional dyspepsia
Giovanni Sarnelli1, Raffaella Grasso, Enzo Ierardi
1Gastroenterologia, Dipartimento di Medicina Clinica e Sperimentale, Università Federico II, Napoli, Italy.
Digestion
|July 19, 2005
Summary
Constipation and functional dyspepsia symptoms are not significantly associated, nor are they linked to specific gastrointestinal motility issues. Motor abnormalities in some patients with both conditions did not explain dyspeptic symptom development.
Area of Science:
- Gastroenterology
- Digestive Physiology
- Clinical Nutrition
Background:
- Constipation frequently co-occurs with dyspeptic symptoms.
- The relationship between specific dyspeptic symptoms and altered gastrointestinal (GI) motility in constipated patients requires further investigation.
Purpose of the Study:
- To investigate the association between constipation and specific dyspeptic symptoms.
- To evaluate GI motility parameters in patients with constipation and functional dyspepsia.
Main Methods:
- 42 patients with constipation and varying dyspepsia symptoms were enrolled.
- Scintigraphic gastric emptying, colonic transit time, and gallbladder contraction were assessed.
Main Results:
- No significant correlation was found between individual constipation and dyspepsia symptoms or their severity.
- While severe nausea correlated with faster colonic transit, multivariate analysis indicated severe postprandial fullness was associated with delayed gastric emptying (t1/2) and impaired gallbladder contraction.
Conclusions:
- Constipation severity or specific symptoms are not linked to functional dyspepsia.
- Motor abnormalities in the colon and proximal GI tract in some constipated dyspeptic patients do not appear to cause specific dyspeptic symptoms.