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Related Experiment Videos

Hyperparathyroidism accompanying multiple myeloma.

Nick Patel1, Arunabh Talwar, Laura Donahue

  • 1Department of Medicine, North Shore University Hospital, Manhasset, New York 11030, USA.

Clinical Nuclear Medicine
|July 19, 2005
PubMed
Summary
This summary is machine-generated.

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Persistent hypercalcemia after multiple myeloma treatment can indicate a coexisting parathyroid adenoma. Surgical removal of the benign parathyroid adenoma resolved the hypercalcemia in this rare case.

Area of Science:

  • Endocrinology
  • Oncology
  • Neoplasms

Background:

  • Hypercalcemia is a common complication of various benign and malignant conditions.
  • Multiple myeloma is a known cause of hypercalcemia.
  • Co-occurrence of hypercalcemia causes is rare but possible.

Observation:

  • A patient with multiple myeloma presented with persistent hypercalcemia despite appropriate treatment.
  • Further investigations revealed elevated parathormone (PTH) levels and scintigraphic evidence of a parathyroid adenoma.
  • This suggests a dual etiology for the hypercalcemia.

Findings:

  • The patient's hypercalcemia resolved after surgical excision of the benign parathyroid adenoma.
  • This case highlights the possibility of concurrent multiple myeloma and primary hyperparathyroidism.

Related Experiment Videos

  • Only 18 similar cases have been reported in the literature.

    • Implications:

    • Clinicians should consider secondary causes of hypercalcemia even after treating the primary malignancy.
    • Elevated PTH levels in hypercalcemic patients with malignancy warrant thorough investigation for parathyroid pathology.
    • This case underscores the importance of comprehensive diagnostic workups for refractory hypercalcemia.