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Related Experiment Videos

Using protein/creatinine ratios in random urine.

Mitsuhiro Watanabe1, Kazuhiko Funabiki, Toshinao Tsuge

  • 1Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.

Journal of Clinical Laboratory Analysis
|July 19, 2005
PubMed
Summary

A new Multistix PRO IOLS test paper allows for creatinine correction, simplifying urinary protein assessment. This novel test accurately predicts daily protein excretion from single urine samples, aiding in renal disease management.

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Area of Science:

  • Nephrology
  • Clinical Chemistry
  • Biomedical Diagnostics

Background:

  • Accurate assessment of urinary protein is crucial for diagnosing and monitoring renal diseases.
  • Conventional methods for urinary protein measurement can be time-consuming and require timed urine collections.
  • The development of rapid, reliable point-of-care tests is essential for improving patient management.

Purpose of the Study:

  • To evaluate the performance of the novel Multistix PRO IOLS test paper for assessing urinary protein.
  • To determine the correlation between protein (P) and creatinine (C) ratios measured by the new test paper and quantitative methods.
  • To assess the reliability of the new test paper using spot urine samples compared to 24-hour collections.

Main Methods:

  • The Multistix PRO IOLS test paper, featuring an altered +/- region for creatinine correction, was used.

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  • Urinary samples from 235 patients with various renal diseases were analyzed.
  • Qualitative and quantitative measurements of urinary protein and creatinine were performed and correlated.

    • Main Results:

    • A good correlation was observed between the protein-to-creatinine (P/C) ratio measured by the new test paper and quantitative analysis.
    • The P/C ratio obtained using the new test paper showed good correlation between 24-hour urine collections and spot urine samples.
    • Results from single, untimed urine samples accurately predicted the amount of protein excreted during the day.

    Conclusions:

    • The Multistix PRO IOLS test paper provides a reliable method for assessing urinary protein levels with creatinine correction.
    • The test enables accurate prediction of daily protein excretion from readily available spot urine samples.
    • This facilitates more convenient and efficient monitoring of renal disease progression.