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[Myocardial protective effect of puerarin injection in children with severe pneumonia]
Ya-li Wang1, Wei Liu, Ping Jiang
1Department of Pedatrics, Hospital Affiliated to Weifang Medical College, Shandong. xftj1234@sina.com
Insights
Puerarin injection (PI) protects children's hearts from severe pneumonia damage. This myocardial protective measure improves heart function with fewer adverse effects than FDP, making it suitable for clinical use.
Area of Science:
- Pediatrics
- Cardiology
- Pharmacology
Background:
- Severe pneumonia in children can cause significant myocardial damage and heart failure.
- Early intervention with myocardial protective measures is crucial for improving patient prognosis.
Purpose of the Study:
- To evaluate the myocardial protective effects of puerarin injection (PI) in pediatric patients diagnosed with severe pneumonia.
- To compare the efficacy and safety of PI with fructose-1,6-disphosphate (FDP) in managing myocardial dysfunction associated with severe pneumonia.
Main Methods:
- A study involving 100 children with pneumonia, divided into mild (CG) and severe (SG) groups.
- The SG group received conventional treatment plus either PI or FDP for myocardial protection.
- Measurements included serum myocardial zymogram, ECG, and cardiac blood flow via Ultrasound Doppler.
Main Results:
- Myocardial damage indicators correlated with pneumonia severity.
- Cardiac blood flow parameters indicated reduced myocardial contractility (P < 0.01).
- Both PI and FDP demonstrated myocardial protection and improved heart function with no significant difference in efficacy (P > 0.05); PI showed fewer adverse effects.
Conclusions:
- Severe pneumonia poses a risk of myocardial damage and heart failure in children.
- Serum myocardial zymographic parameters, particularly CK-MB, are sensitive indicators of myocardial injury.
- Puerarin injection is effective and safe for protecting the myocardium and improving cardiac function in children with severe pneumonia, supporting its clinical application.
Objective:
To investigate the myocardial protective effect of puerarin injection (PI) in children with severe pneumonia.
Methods:
One hundred children with pneumonia enrolled were divided into two groups according to their condition of illness. Forty-eight children of mild condition in the common group (CG) were treated with conventional treatment and 52 children of serious condition in the severe group (SG) were treated with conventional treatment with additional PI or fructose-1,6-disphosphate (FDP) for myocardial protection. The parameters of serum myocardial zymogram, ECG and cardiac blood flow were measured and the effects of PI and FDP in patients of serious condition were compared.
Results:
Change of serum myocardial zymographic parameters was indirectly proportional to the severity of childrens condition. The reduction of myocardial contractive function was demonstrated by the change of cardiac blood flow parameters in Ultrasound Doppler examination (P < 0.01). Both PI and FDP had the effect in protecting myocardium and improving heart function, showing insignificant difference between their efficacy (P > 0.05), but PI had less stimulation to vessels and without any obvious adverse reaction.
Conclusion:
Severe pneumonia in children can lead to myocardial damage and heart failure, and early applying of myocardial protective measure can significantly improve the prognosis of patient. Myocardial zymographic parameters, especially the CK-MB, are sensitive and important indexes for detecting myocardial injury. PI has effects in protecting myocardium and improving heart function, and therefore, is suitable for spreading and applying in clinical practice.
