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Lipid peroxidation, superoxide dismutase and catalase activities in brain tumor tissues
B Popov1, V Gadjeva, P Valkanov
1Department of Chemistry and Biochemistry, Medical Faculty, Thracian University, Stara Zagora, Bulgaria.
Abstract:
Free radical-mediated damages may play an important role in cancerogenesis. To investigate their relevance in the cancer process, malonyl dialdehyde (MDA) level, superoxide dismutase (SOD), and catalase (CAT) activities were determined in the normal brain tissue and brain tumor tissue. When compared with the normal brain tissue, we have detected: (i) significantly lower MDA concentration in brain tumor tissue (1.63 nmol/mg Pr vs 2.04 nmol/mg Pr; p = 0.03); (ii) SOD activity in brain tumor tissue was significantly lower (3.15 U/mg Pr vs 4.97 U/mg Pr; p = 0.0002); and (iii) CAT activity in brain tumor tissue was 106.3% higher than that in controls.
